P(OEt)3-Mediated Formal S–H Insertion: Reductive Couplings of Isatins with Thiols to Generate 3-Sulfenylated Oxindoles

Abstract A new P(OEt) 3 -mediated formal S–H bond-insertion reaction of isatins into thiols for the synthesis of valuable 3-sulfenylation oxindoles has been developed. This approach takes advantage of the unique reactivity of Kukhtin–Ramirez adducts to allow direct reductive S–H functionalization wi...

Full description

Saved in:
Bibliographic Details
Published in:Synthesis (Stuttgart) 2020-09, Vol.52 (18), p.2689-2697
Main Authors: Huang, Tiao, Liu, Li, Wang, Qinghe, Kong, Dulin, Wu, Mingshu
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract A new P(OEt) 3 -mediated formal S–H bond-insertion reaction of isatins into thiols for the synthesis of valuable 3-sulfenylation oxindoles has been developed. This approach takes advantage of the unique reactivity of Kukhtin–Ramirez adducts to allow direct reductive S–H functionalization with commercially available and bench-stable starting materials.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0040-1707147