Electrochemical Synthesis of Quinazolinones by the Metal-Free and Acceptor-Free Dehydrogenation of 2-Aminobenzamides

Abstract An efficient approach has been developed for the construction of quinazolin-4(3 H )-ones by the selective anodic dehydrogenative oxidation/cyclization of benzylic chlorides and 2-aminobenzamides. The method features acceptor-free and metal-free dehydrogenation of amines to imines; a subsequ...

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Bibliographic Details
Published in:Synlett 2020-11, Vol.31 (18), p.1795-1799
Main Authors: Yao, Yan, Meng, Xiu-Jin, Teng, Qing-Hu, Chen, Yan-Yan
Format: Article
Language:English
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Summary:Abstract An efficient approach has been developed for the construction of quinazolin-4(3 H )-ones by the selective anodic dehydrogenative oxidation/cyclization of benzylic chlorides and 2-aminobenzamides. The method features acceptor-free and metal-free dehydrogenation of amines to imines; a subsequent intermolecular addition provides the products in moderate to good yields.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0040-1707248