Acetic Acid Promoted Direct Iodination of Terminal Alkynes with N-Iodosuccinimide: Efficient Preparation of 1-Iodoalkynes

Abstract An efficient and highly chemoselective approach for the direct iodination of terminal alkynes using acetic acid as N -iodosuccinimide activated reagent under metal-free conditions has been developed. This facile process tolerates a variety of terminal alkynes and provides the desired produc...

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Bibliographic Details
Published in:Synlett 2020-07, Vol.31 (11), p.1102-1106
Main Authors: Yao, Ming, Zhang, Jingjing, Yang, Sen, Liu, E, Xiong, Hangxing
Format: Article
Language:English
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Summary:Abstract An efficient and highly chemoselective approach for the direct iodination of terminal alkynes using acetic acid as N -iodosuccinimide activated reagent under metal-free conditions has been developed. This facile process tolerates a variety of terminal alkynes and provides the desired products in good to excellent yields (up to 99%).
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0040-1708002