Diversity-Oriented Synthesis of Coumarin-Fused Cyclopentanones via a Nucleophilic Phosphine Controlled Cascade Reaction

Abstract A phosphine-promoted intermolecular annulation reaction of functionalized 3-benzoyl coumarin with alkynone has been disclosed. This reaction was found to be highly dependent on the nucleophilicity of the phosphine. Two classes of coumarin-fused cyclopentanones were selectively afforded in m...

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Bibliographic Details
Published in:Synlett 2022-08, Vol.33 (13), p.1282-1286
Main Authors: Huang, Qi, Fu, Junfeng, Chang, Zhixin, Gan, Wenhao, Wang, Yongjiang, Han, Xiaoyu
Format: Article
Language:English
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Summary:Abstract A phosphine-promoted intermolecular annulation reaction of functionalized 3-benzoyl coumarin with alkynone has been disclosed. This reaction was found to be highly dependent on the nucleophilicity of the phosphine. Two classes of coumarin-fused cyclopentanones were selectively afforded in moderate to good yields with excellent diastereoselectivities under the mild reaction conditions.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0041-1738399