Synthesis of Symmetrical Disulfides by an NIS/PPh3-Mediated Reductive Self-Coupling of Sulfonyl Hydrazides

The present study discloses an NIS/PPh3-mediated reductive self-coupling of arylsulfonyl hydrazides to prepare symmetric diaryl disulfides. This methodology has a broad functional-group tolerance and a high scalability. This strategy permits the introduction of sulfonyl hydrazides into the synthesis...

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Bibliographic Details
Published in:Synlett 2024-07, Vol.35 (12), p.1453-1457
Main Authors: Yadav, Ashvani, Gond, Amrit, Prasad, Virendra
Format: Article
Language:English
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Summary:The present study discloses an NIS/PPh3-mediated reductive self-coupling of arylsulfonyl hydrazides to prepare symmetric diaryl disulfides. This methodology has a broad functional-group tolerance and a high scalability. This strategy permits the introduction of sulfonyl hydrazides into the synthesis of symmetrical organic disulfides without the use of a catalyst or base, and symmetrical aromatic disulfides can be prepared in moderate to excellent isolated yields from inexpensive and readily available starting materials.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0041-1738457