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Inhibition of Degranulation of RBL-2H3 Cells by Extracts and Compounds from Armillaria ostoyae
Abstract Armillaria ostoyae (Romagn.) Herink is an edible honey mushroom from the family Physalacriaceae (Agaricales, Basidiomycota). Dichloromethane extracts of mushroom mycelium and fruiting bodies exhibited a significant degranulation inhibiting effect on RBL-2H3 cells using noncytotoxic concentr...
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Published in: | Planta Medica International Open (Online) 2017-02, Vol.4 (1), p.e1-e7 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Abstract
Armillaria ostoyae
(Romagn.) Herink is an edible honey mushroom from the family Physalacriaceae (Agaricales, Basidiomycota). Dichloromethane extracts of mushroom mycelium and fruiting bodies exhibited a significant degranulation inhibiting effect on RBL-2H3 cells using noncytotoxic concentrations. Bioactivity-guided fractionation of the mycelial dichloromethane extract led to the isolation of sesquiterpen aryl esters. Methyl linoleate could also be isolated. These substances were obtained from
A. ostoyae
for the first time, with one compound representing an undescribed natural product. Purified compounds melleolide H and J inhibited degranulation significantly.
A. ostoyae
could be a candidate for support of allergy treatments. |
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ISSN: | 2509-9264 2509-6656 |
DOI: | 10.1055/s-0042-121608 |