Rare Earth Salt Catalyzed Asymmetric Diels-Alder Reaction with a Chiral Dienophile in Supercritical Carbon Dioxide: Enhancement Effect on Stereoselectivity

Abstract The rare earth(III) salt catalyzed asymmetric Diels-Alder reaction of cyclopentadiene with a chiral dienophile in supercritical carbon dioxide (scCO 2 ) proceeded rapidly to give the adduct with a higher diastereoselectivity than that in dichloromethane; optimization of the CO 2 density inc...

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Bibliographic Details
Published in:Synlett 2002-01, Vol.2002 (1), p.134-136
Main Authors: Fukuzawa, Shin-Ichi, Metoki, Ken, Komuro, Yoshitaka, Funazukuri, Toshitaka
Format: Article
Language:English
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Summary:Abstract The rare earth(III) salt catalyzed asymmetric Diels-Alder reaction of cyclopentadiene with a chiral dienophile in supercritical carbon dioxide (scCO 2 ) proceeded rapidly to give the adduct with a higher diastereoselectivity than that in dichloromethane; optimization of the CO 2 density increased the de value up to 77%.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2002-19348