Juliá-Colonna Asymmetric Epoxidation in a Continuously Operated Chemzyme Membrane Reactor

Abstract Two novel soluble polymer-bound oligo-L-leucines 2 and 5, which can be retained by a membrane reactor system, have been prepared and used as catalysts for the continuously operated asymmetric epoxidation of chalcone. The optimized batch reaction conditions yield epoxychalcone in high enanti...

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Bibliographic Details
Published in:Synlett 2002, Vol.2002 (5), p.707-710
Main Authors: Tsogoeva, Svetlana B., Wöltinger, Jens, Jost, Carsten, Reichert, Dietmar, Kühnle, Adolf, Krimmer, Hans-Peter, Drauz, Karlheinz
Format: Article
Language:English
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Summary:Abstract Two novel soluble polymer-bound oligo-L-leucines 2 and 5, which can be retained by a membrane reactor system, have been prepared and used as catalysts for the continuously operated asymmetric epoxidation of chalcone. The optimized batch reaction conditions yield epoxychalcone in high enantioselectivities (up to 94%) and conversions (over 99%) after 15 minutes.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2002-25352