Asymmetric Cyanosilylation of Ketones Catalyzed by Chiral N-Oxide-titanium (IV) Complex

Abstract A new approach for the asymmetric addition of trime­thylsilylcyanide to ketones using chiral N-oxide-Ti(IPrO) 4 complex as catalyst is reported. The screening of a number of chiral N-oxides has resulted in a system that gives the O-TMS ethers of cyanohydrins in good isolated yields with ena...

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Bibliographic Details
Published in:Synlett 2002, Vol.2002 (8), p.1353-1355
Main Authors: Shen, Yongcun, Feng, Xiaoming, Zhang, Guolin, Jiang, Yaozhong
Format: Article
Language:English
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Summary:Abstract A new approach for the asymmetric addition of trime­thylsilylcyanide to ketones using chiral N-oxide-Ti(IPrO) 4 complex as catalyst is reported. The screening of a number of chiral N-oxides has resulted in a system that gives the O-TMS ethers of cyanohydrins in good isolated yields with enantiomeric excesses of up to 69%.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2002-32983