Synthesis of (+/-)-Curcumene Ether

Abstract A 9 step synthesis of (+/-)-curcumene ether is described starting from 5-bromo-2-methyl-2-pentene and 2-amino-5-methylphenol in 7% overall yield using an intramolecular Heck reaction as the key transformation to generate a stereogenic quaternary center.

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Bibliographic Details
Published in:Synlett 2003-01, Vol.2003 (9)
Main Authors: Vickers, Troy D., Keay, Brian A.
Format: Article
Language:English
Subjects:
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Description
Summary:Abstract A 9 step synthesis of (+/-)-curcumene ether is described starting from 5-bromo-2-methyl-2-pentene and 2-amino-5-methylphenol in 7% overall yield using an intramolecular Heck reaction as the key transformation to generate a stereogenic quaternary center.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2003-40343