Phosphonodithioformates: Efficient Three-Component Coupling of Dialkyl phosphites, Carbon Disulfide, and Alkyl Halides in the Presence of Cesium Carbonate and Tetrabutylammonium Iodide

Abstract A mild one-pot, three-component coupling reaction uniting­ a dialkyl phosphite, carbon disulfide (CS 2 ) and an alkyl halid­e for the mild and efficient synthesis of phosphonodithio­formates using cesium carbonate (Cs 2 CO 3 ) and tetrabutyl­ammonium iodide (TBAI) was developed. Various dia...

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Bibliographic Details
Published in:Synlett 2003-10, Vol.2003 (13), p.2037-2041
Main Authors: Fox, Daniel L., Whitely, Nathan R., Cohen, Richard J., Salvatore, Ralph Nicholas
Format: Article
Language:English
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Summary:Abstract A mild one-pot, three-component coupling reaction uniting­ a dialkyl phosphite, carbon disulfide (CS 2 ) and an alkyl halid­e for the mild and efficient synthesis of phosphonodithio­formates using cesium carbonate (Cs 2 CO 3 ) and tetrabutyl­ammonium iodide (TBAI) was developed. Various dialkyl phosphites were examined using a diverse array of alkyl halides, and these improved reaction conditions were found to be highly selective­ producing the title compounds exclusively in moderate to high yields.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2003-41482