A Novel Catalytic Three-Component Synthesis (Kabachnick-Fields Reaction) of α-Aminophosphonates from Ketones

Abstract A novel and highly convenient catalytic variant of the synthesis of α-aminophosphonates on basis of the Kabachnik-Fields reaction [three-component reaction of ketones, diethylphosphite and either benzylamine (series A) of ammonium carbonate (series B)] in the presence of tetra-TERT-butylpht...

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Published in:Synlett 2003-12, Vol.2003 (15), p.2321-2324
Main Authors: Matveeva, Elena D., Podrugina, Tatyana A., Tishkovskaya, Elena V., Tomilova, Larisa G., Zefirov, Nikolay S.
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container_issue 15
container_start_page 2321
container_title Synlett
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creator Matveeva, Elena D.
Podrugina, Tatyana A.
Tishkovskaya, Elena V.
Tomilova, Larisa G.
Zefirov, Nikolay S.
description Abstract A novel and highly convenient catalytic variant of the synthesis of α-aminophosphonates on basis of the Kabachnik-Fields reaction [three-component reaction of ketones, diethylphosphite and either benzylamine (series A) of ammonium carbonate (series B)] in the presence of tetra-TERT-butylphthalocyanines has been developed. This method affords α-aminophosphonates in acceptable yields for various ketones, including cyclic, sterically hindered and cage ketones. The unsubstituted α-aminophosphonic acids were also obtained from the corresponding esters of series B.
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title A Novel Catalytic Three-Component Synthesis (Kabachnick-Fields Reaction) of α-Aminophosphonates from Ketones
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