Transition Metal-based Lewis Acid Catalyzed Ring Opening of Epoxides Using Amines under Solvent-Free Conditions

Abstract Transition metal-based Lewis acids, such as SnCl 4 ·5H 2 O, Co(OAc) 2 ·4H 2 O, Ni(OAc) 2 ·2H 2 O, NiCl 2 , Mn(OAc) 2 ·4H 2 O etc. catalyze the nucleophilic opening of epoxide rings by amines leading to the efficient synthesis of β-amino alcohols. The reaction works well with aromatic and al...

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Bibliographic Details
Published in:Synlett 2004-04, Vol.2004 (5), p.0846-0850
Main Authors: Zhao, Pei-Qing, Xu, Li-Wen, Xia, Chun-Gu
Format: Article
Language:English
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Summary:Abstract Transition metal-based Lewis acids, such as SnCl 4 ·5H 2 O, Co(OAc) 2 ·4H 2 O, Ni(OAc) 2 ·2H 2 O, NiCl 2 , Mn(OAc) 2 ·4H 2 O etc. catalyze the nucleophilic opening of epoxide rings by amines leading to the efficient synthesis of β-amino alcohols. The reaction works well with aromatic and aliphatic amines in high yields under solvent-free conditions.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2004-817780