Double Stereodifferentiating Aldol Reactions Based on Chiral Ketones Derived from Lactic Acid: Synthesis of C1-C6 Fragment of Erythronolides

Abstract Highly stereoselective titanium-mediated aldol additions of ethyl ketones derived from lactic acid to α-methyl-β-OTBDPS chiral aldehydes are documented. One of these double stereodifferentiating processes represents the key step of a straightforward and efficient synthetic approach to the C...

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Bibliographic Details
Published in:Synlett 2004-10, Vol.2004 (12), p.2127-2130
Main Authors: Solsona, Joan G., Nebot, Joaquim, Romea, Pedro, Urpí, Fèlix
Format: Article
Language:English
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Summary:Abstract Highly stereoselective titanium-mediated aldol additions of ethyl ketones derived from lactic acid to α-methyl-β-OTBDPS chiral aldehydes are documented. One of these double stereodifferentiating processes represents the key step of a straightforward and efficient synthetic approach to the C1-C6 fragment of erythronolides.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2004-831332