Nickel-Catalyzed Cross-Coupling Reactions of 4-Mesylcoumarins with Aryl Halides: Facile Synthesis of 4-Substituted Coumarins

Abstract A new and efficient nickel-catalyzed cross-coupling reaction between 4-mesylcoumarins and aryl halides was developed to give a number of 4-arylcoumarins in good yield under mild conditions. Unlike the previously reported coupling examples, this new method allows the direct cross-coupling of...

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Bibliographic Details
Published in:Synlett 2004-11, Vol.2004 (13), p.2364-2368
Main Authors: Lei, Jian-Guang, Xu, Ming-Hua, Lin, Guo-Qiang
Format: Article
Language:English
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Summary:Abstract A new and efficient nickel-catalyzed cross-coupling reaction between 4-mesylcoumarins and aryl halides was developed to give a number of 4-arylcoumarins in good yield under mild conditions. Unlike the previously reported coupling examples, this new method allows the direct cross-coupling of 4-mesylcoumarins with aryl- or vinyl halides in the NiCl 2 (PPh 3 ) 2 /PPh 3 /Zn/toluene system. This has greatly facilitated the synthesis of biologically useful 4-substituted coumarins.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2004-832818