Synthesis of 5-Hydroxy- and 5-Amino-1-tosyl-5-phenyl-3-(2-arylvinyl)-4,5-­dihydropyrazoles

Abstract The reaction of β-arylacryloyloxiranes with tosylhydrazine leads to unexpected 5-hydroxysubstituted Δ 2 -pyrazolines. A series of 3-styryl substituted pyrazoles and 5-amino-Δ 2 -pyrazolines were synthesized from the 5-hydroxy-Δ 2 -pyrazolines. The mechanism of this process has been proposed...

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Bibliographic Details
Published in:Synlett 2005-02, Vol.2005 (3), p.485-486
Main Authors: Kuz’menok, Nina M., Koval’chuk, Tatyana A., Zvonok, Alexander M.
Format: Article
Language:English
Subjects:
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Summary:Abstract The reaction of β-arylacryloyloxiranes with tosylhydrazine leads to unexpected 5-hydroxysubstituted Δ 2 -pyrazolines. A series of 3-styryl substituted pyrazoles and 5-amino-Δ 2 -pyrazolines were synthesized from the 5-hydroxy-Δ 2 -pyrazolines. The mechanism of this process has been proposed based on current and previous results.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-862353