Development of Chiral Catalysts by Asymmetric Activation for Highly Enantioselective Diethylzinc Addition to Imines

Abstract Based on the asymmetric activation concept, a library of chiral zinc complexes in situ formed by the combination of diimines derived from chiral 1,2-diphenyl-ethanene-1,2-diamine, BINOL derivatives, and diethylzinc are evaluated in the asymmetric addition of diethylzinc to N-acylimines. In...

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Bibliographic Details
Published in:Synlett 2005-03, Vol.2005 (4), p.615-618
Main Authors: Zhang, Hai-Le, Liu, Hua, Cui, Xin, Mi, Ai-Qiao, Jiang, Yao-Zhong, Gong, Liu-Zhu
Format: Article
Language:English
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Summary:Abstract Based on the asymmetric activation concept, a library of chiral zinc complexes in situ formed by the combination of diimines derived from chiral 1,2-diphenyl-ethanene-1,2-diamine, BINOL derivatives, and diethylzinc are evaluated in the asymmetric addition of diethylzinc to N-acylimines. In the presence of 10 mol% L3ZNA1, high enantioselectivities and yields were provided for a wide range of aromatic imines in 1,2-dichloroethane at -25 °C.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-863709