Palladium-Catalyzed Selective Amination of Haloaromatics on KF-Alumina Surface

Abstract An efficient palladium-catalyzed amination, including polyaminations of aromatic bromides mediated on a surface of KF-alumina, is reported. The solvent-free one-pot protocol avoids the use of a strong base (sodium TERT-butoxide) making it applicable to substrates containing a base-sensitive...

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Bibliographic Details
Published in:Synlett 2005-05, Vol.2005 (8), p.1275-1278
Main Authors: Basu, Basudeb, Das, Pralay, Nanda, Ashish K., Das, Sajal, Sarkar, Sajal
Format: Article
Language:English
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Summary:Abstract An efficient palladium-catalyzed amination, including polyaminations of aromatic bromides mediated on a surface of KF-alumina, is reported. The solvent-free one-pot protocol avoids the use of a strong base (sodium TERT-butoxide) making it applicable to substrates containing a base-sensitive functional group. It proceeds without concomitant reductive bromination and provides access to selective amination of polyhaloaromatics.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-865241