Novel Dendritic Ligands of Chiral 1,2-Diamine and Their Application in Asymmetric Hydrogenation of Simple Aryl Ketones

Abstract Novel dendritic chiral vicinal diamine ligands have been synthesized and a series of dendritic Ru(BINAP)(diamine) catalysts were developed for asymmetric hydrogenation of a variety of ­simple aryl ketones in good catalytic activity and high enantioselectivity, as well as facile catalyst rec...

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Bibliographic Details
Published in:Synlett 2005-06, Vol.2005 (10), p.1591-1595
Main Authors: Liu, Weiguo, Cui, Xin, Cun, Linfeng, Wu, Jun, Zhu, Jin, Deng, Jingen, Fan, Qinghua
Format: Article
Language:English
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Summary:Abstract Novel dendritic chiral vicinal diamine ligands have been synthesized and a series of dendritic Ru(BINAP)(diamine) catalysts were developed for asymmetric hydrogenation of a variety of ­simple aryl ketones in good catalytic activity and high enantioselectivity, as well as facile catalyst recycling. An increase of enantio­selectivities was obtained by using the dendritic catalysts compared with Noyori catalysts under the same conditions in the case of ­several substrates. Meanwhile, a remarkable structural effect on ­catalytic activity and enantioselectivity, as well as reuse was ­observed.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-869862