A Novel Approach to the Synthesis of N-Substituted 1-C-Aminomethyl Glycofuranosides

Abstract Reductive amination of formyl C-glycofuranosides, easily available from hexose-derived equatorial-2-OH-glycopyranosides by DAST-promoted ring contraction, afforded N-substituted 1-C-aminomethyl glycofuranosides in most cases in high yields.

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Bibliographic Details
Published in:Synlett 2006-01, Vol.2006 (1), p.0045-0048
Main Authors: Vera-Ayoso, Yolanda, Borrachero, Pastora, Cabrera-Escribano, Francisca, Gómez-Guillén, Manuel, Vogel, Pierre
Format: Article
Language:English
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Summary:Abstract Reductive amination of formyl C-glycofuranosides, easily available from hexose-derived equatorial-2-OH-glycopyranosides by DAST-promoted ring contraction, afforded N-substituted 1-C-aminomethyl glycofuranosides in most cases in high yields.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-922762