Manganese-Promoted β-Elimination Reactions: Totally Stereoselective Synthesis of (E)-α,β-Unsaturated Esters

Abstract Stereoselective β-elimination of 2-bromo-3-hydroxy­esters is achieved by using non-preactivated manganese and tri­methylsilyl chloride, to yield (E)-α,β-unsaturated esters with total diastereoselectivity.

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Bibliographic Details
Published in:Synlett 2006-02, Vol.2006 (2), p.315-317
Main Authors: Concellón, José M., Rodríguez-Solla, Humberto, del Amo, Vicente
Format: Article
Language:English
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Summary:Abstract Stereoselective β-elimination of 2-bromo-3-hydroxy­esters is achieved by using non-preactivated manganese and tri­methylsilyl chloride, to yield (E)-α,β-unsaturated esters with total diastereoselectivity.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-923592