A Focused Library of Tetrahydropyrimidinone Amides via a Tandem Biginelli-Ugi Multi-Component Process

Abstract A second generation focused library of 30 tetrahydropyrimidinone amides was prepared. The design was based on the structure of an Hsp70 modulator. This small library demonstrates the utility of tandem multi-component reactions in structure-activity relationship studies of biological lead mo...

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Bibliographic Details
Published in:Synlett 2006-09, Vol.2006 (14), p.2334-2338
Main Authors: Werner, Stefan, Turner, David M., Lyon, Michael A., Huryn, Donna M., Wipf, Peter
Format: Article
Language:English
Subjects:
cluster
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Summary:Abstract A second generation focused library of 30 tetrahydropyrimidinone amides was prepared. The design was based on the structure of an Hsp70 modulator. This small library demonstrates the utility of tandem multi-component reactions in structure-activity relationship studies of biological lead molecules. The tandem Biginelli-Ugi multi-component reaction facilitated the effective variation of four different substituents and allowed the synthesis of the library members in a sequence of only two one-pot reactions.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2006-949648