Synthesis of a Protected δ-Glyco-amino Acid Building Block for Incorporation into Peptide Chains

ABSTRACT The synthesis of a suitably protected sugar amino acid (δ-glyco-amino acid) as a building block to be incorporated into the peptide chain (N-terminus) of bioactive peptide analogues is described. Its efficient coupling reactions with pilot amino acids as well as dipeptides have been accompl...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2007-03, Vol.2007 (6), p.845-852
Main Authors: Paloumbis, George, Petrou, Christos C., Nock, Berthold, Maina, Theodosia, Pairas, George, Tsoungas, Petros G., Cordopatis, Paul
Format: Article
Language:English
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Summary:ABSTRACT The synthesis of a suitably protected sugar amino acid (δ-glyco-amino acid) as a building block to be incorporated into the peptide chain (N-terminus) of bioactive peptide analogues is described. Its efficient coupling reactions with pilot amino acids as well as dipeptides have been accomplished by standard peptide chemistry.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2007-965942