Palladium-Catalyzed Couplings of Heteroaryl Amines with Aryl Halides Using Sodium Phenolate as the Stoichiometric Base

Abstract Heteroaryl amines are efficiently coupled (in two hours) to aryl halides with catalytic Pd 2 (dba) 3 and Xantphos to provide the corresponding biaryl amines under microwave and standard thermal conditions. The use of organic-soluble sodium phenolate (NaOPh) as the stoichiometric base promot...

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Bibliographic Details
Published in:Synlett 2007-09, Vol.2007 (15), p.2331-2336
Main Authors: Schulte II, James P., Tweedie, Scott R.
Format: Article
Language:English
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Summary:Abstract Heteroaryl amines are efficiently coupled (in two hours) to aryl halides with catalytic Pd 2 (dba) 3 and Xantphos to provide the corresponding biaryl amines under microwave and standard thermal conditions. The use of organic-soluble sodium phenolate (NaOPh) as the stoichiometric base promotes facile coupling of a variety of substrates in excellent yields.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2007-985597