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Synthesis of a Hydroxyethylene Dipeptide Isostere, a Core Unit of the HIV Protease Inhibitors Ritonavir and Lopinavir, and Its C-5 Epimer

Abstract A short synthesis of a hydroxyethylene dipeptide iso­stere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2008-10, Vol.2008 (19), p.3061-3064
Main Authors: Bhaskar, Gopishetti, Kumar, Anchoori Ravi, Ramu, Errabelli, Rao, Batchu Venkateswara
Format: Article
Language:English
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Description
Summary:Abstract A short synthesis of a hydroxyethylene dipeptide iso­stere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2008-1067252