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Synthesis of a Hydroxyethylene Dipeptide Isostere, a Core Unit of the HIV Protease Inhibitors Ritonavir and Lopinavir, and Its C-5 Epimer
Abstract A short synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.
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Published in: | Synthesis (Stuttgart) 2008-10, Vol.2008 (19), p.3061-3064 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Abstract
A short synthesis of a hydroxyethylene dipeptide isostere,
a core unit of the HIV protease inhibitors ritonavir and lopinavir,
and its C-5 epimer is described. |
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ISSN: | 0039-7881 1437-210X |
DOI: | 10.1055/s-2008-1067252 |