Iron(III) Chloride as Mild and Efficient Reagent for the α-Thiocyanation of Ketones: An Expedient Synthesis of α-Oxo Thiocyanates

Abstract A simple and efficient method for the α-thiocyanation of ketones has been developed; anhydrous iron(III) chloride is used under mild conditions to produce α-oxo thiocyanates in good to high yields and with high selectivity. The use of inexpensive and readily available iron(III) chloride mak...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2008-04, Vol.2008 (8), p.1283-1287
Main Authors: Yadav, Jhillu S., Reddy, Basi V., Reddy, Ummareddy V., Chary, Darshanoju N.
Format: Article
Language:English
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Summary:Abstract A simple and efficient method for the α-thiocyanation of ketones has been developed; anhydrous iron(III) chloride is used under mild conditions to produce α-oxo thiocyanates in good to high yields and with high selectivity. The use of inexpensive and readily available iron(III) chloride makes this procedure simple, convenient, and practical.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2008-1072517