Novel N,S-Phenacyl Protecting Group and Its Application for Peptide ­Synthesis

Abstract The phenacyl group can be introduced onto amino and thio groups by N,S-alkylation reactions. Conversely, these groups are removed rapidly by employing magnesium in acetic acid. This protecting group was successfully applied to a short peptide synthesis of Boc-L-Cys-Gly-OMe.

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Bibliographic Details
Published in:Synlett 2008-07, Vol.2008 (12), p.1907-1909
Main Authors: Tang, Guo, Ji, Tao, Hu, An-Fu, Zhao, Yu-Fen
Format: Article
Language:English
Subjects:
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Description
Summary:Abstract The phenacyl group can be introduced onto amino and thio groups by N,S-alkylation reactions. Conversely, these groups are removed rapidly by employing magnesium in acetic acid. This protecting group was successfully applied to a short peptide synthesis of Boc-L-Cys-Gly-OMe.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2008-1077887