Metal-Free Reductive Cleavage of N-O Bonds in Weinreb Amides by an Organic Neutral Super-Electron Donor

Abstract The scope of neutral organic super-electron donors as reducing agents has been extended to include the reductive cleavage of N-O bonds in Weinreb amides. This methodology proved to be applicable to a large array of substrates to afford their reduced counterparts in good to excellent yields....

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Bibliographic Details
Published in:Synlett 2008-08, Vol.2008 (14), p.2132-2136
Main Authors: Cutulic, Sylvain P., Murphy, John A., Farwaha, Hardeep, Zhou, Sheng-Ze, Chrystal, Ewan
Format: Article
Language:English
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Summary:Abstract The scope of neutral organic super-electron donors as reducing agents has been extended to include the reductive cleavage of N-O bonds in Weinreb amides. This methodology proved to be applicable to a large array of substrates to afford their reduced counterparts in good to excellent yields. The variation in reactivity within the set of tested amides is rationalised.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2008-1078240