Conformation impact in the deformation of DNA TATA-box

The ability to undergo specific deformation in response to conformational changes of some sites of the macromolecule is the key element of DNA genetic activity regulation in biological cells. The deformation of the definite sequences in DNA chain provides an accurate reading of genetic information a...

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Bibliographic Details
Published in:Low temperature physics (Woodbury, N.Y.) N.Y.), 2022-04, Vol.48 (4), p.311-317
Main Authors: Kanevska, P. P., Volkov, S. N.
Format: Article
Language:English
Subjects:
Biological activity
Deoxyribonucleic acid
DNA
Gene sequencing
Nucleotides
Protein synthesis
Reproduction (biology)
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Summary:The ability to undergo specific deformation in response to conformational changes of some sites of the macromolecule is the key element of DNA genetic activity regulation in biological cells. The deformation of the definite sequences in DNA chain provides an accurate reading of genetic information and the process of protein synthesis passing. The model based on the analysis of conformational changes of the TATA nucleotide sequence in DNA double helix is developed. In addition to elastic components (bending, twisting), the presented model includes the conformational rearrangements of the TATA-box. Obtained form, value, and energy of DNA cite deformation allow to offer the probable mechanism of recognition of key DNA sequences and makes it possible to explain the high accuracy of the processes of reproducing of genetic information in biological cells. The formulated physical mechanism of DNA deformation can be one of the main principles of genetic information realization.
ISSN:1063-777X
1090-6517
DOI:10.1063/10.0009735