Electrocatalytic Oxidation of Calcium Folinate on Carboxyl Graphene Modified Cu x O/Cu Electrode

• Published in: Chinese journal of chemical physics 2016-12, Vol.29 (6), p.729-734
• Main Authors: Wang, Li-wen, Wu, Shou-guo, Shi, Tian-yang, Wei, Wei, Pan, Pan
• Format: Article
• Language: English
• ISSN: 1674-0068; 2327-2244
• DOI: 10.1063/1674-0068/29/cjcp1604079

Carboxyl graphene modified Cu x O/Cu electrode was fabricated. The bare copper electrode was firstly anodic polarized in 1.0 mol/L NaOH solution in order to get Cu x O nanoparticles, then the carboxyl graphene (CG) was electrodeposited on the Cu x O/Cu electrode by cyclic potential sweeping. The electrocatalytic oxidation behaviors of calcium folinate (CF) at the graphene modified Cu x O/Cu electrode were investigated by cyclic voltammetry. A positive scan polarization reverse catalytic voltammetry was used to obtain the pure catalytic oxidation current. The graphene modified Cu x O/Cu electrode was served as the electrochemical sensor of CF, a highly sensitivity of 22.0 µA·(µmol/µL)−1cm−2 was achieved, and the current response was linear with increasing CF concentration in the range of 2.0×10−7 mol/L to 2.0×10−5 mol/L, which crossed three orders of magnitude, and the detection limit was found 7.6×10−8 mol/L (S/N=3). In addition, the proposed sensor was successfully applied in determination of CF in drug sample.