Mechanical resonant immunospecific biological detector

We have demonstrated high-sensitivity detection of bacteria using an array of bulk micromachined resonant cantilevers. The biological sensor is a micromechanical oscillator that consists of an array of silicon-nitride cantilevers with an immobilized antibody layer on the surface of the resonator. Me...

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Bibliographic Details
Published in:Applied physics letters 2000-07, Vol.77 (3), p.450-452
Main Authors: Ilic, B., Czaplewski, D., Craighead, H. G., Neuzil, P., Campagnolo, C., Batt, C.
Format: Article
Language:English
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Summary:We have demonstrated high-sensitivity detection of bacteria using an array of bulk micromachined resonant cantilevers. The biological sensor is a micromechanical oscillator that consists of an array of silicon-nitride cantilevers with an immobilized antibody layer on the surface of the resonator. Measured resonant frequency shift as a function of the additional cell loading was observed and correlated to the mass of the specifically bound Escherichia coli O157:H7 cells. Deposition and subsequent detection of E. coli cells was achieved under ambient conditions.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.127006