Optical observation of contrast agent destruction

Fragmentation of an ultrasound contrast agent on the time scale of microseconds provides opportunities for the advancement of microvascular detection, blood flow velocity estimation, and targeted drug delivery. Images captured by high-speed imaging systems show destruction of a microbubble during co...

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Bibliographic Details
Published in:Applied physics letters 2000-08, Vol.77 (7), p.1056-1058
Main Authors: Chomas, James E., Dayton, Paul A., May, Donovan, Allen, John, Klibanov, Alexander, Ferrara, Katherine
Format: Article
Language:English
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Summary:Fragmentation of an ultrasound contrast agent on the time scale of microseconds provides opportunities for the advancement of microvascular detection, blood flow velocity estimation, and targeted drug delivery. Images captured by high-speed imaging systems show destruction of a microbubble during compression. Peak wall velocity of −700 m/s and peak acceleration of 1.2×1012 m/s2 is observed for insonation with a peak pressure of −1.1 MPa and a center frequency of 2.4 MHz. Theoretical calculations of wall velocity and acceleration using a modified Rayleigh–Plesset model predict a peak negative wall velocity of −680 m/s and peak acceleration of 2×1012 m/s2.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.1287519