Adhesion and liquid–liquid phase separation in globular protein solutions

We derive a form of adhesive interaction between protein globules in solution, developing from the premise that amino-acid residues are able to rearrange around a globule–globule contact. We show in this approach that globules only become adhesive above a certain threshold temperature, which is sens...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of chemical physics 2002-04, Vol.116 (15), p.6826-6830
Main Author: Braun, F. N.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We derive a form of adhesive interaction between protein globules in solution, developing from the premise that amino-acid residues are able to rearrange around a globule–globule contact. We show in this approach that globules only become adhesive above a certain threshold temperature, which is sensitive to an osmotic modulus characterizing individual globule elasticity. Above the threshold, adhesive strength increases monotonically with temperature, driving a temperature-reversed liquid–liquid phase separation.
ISSN:0021-9606
1089-7690
DOI:10.1063/1.1461358