Adhesion and liquid–liquid phase separation in globular protein solutions

We derive a form of adhesive interaction between protein globules in solution, developing from the premise that amino-acid residues are able to rearrange around a globule–globule contact. We show in this approach that globules only become adhesive above a certain threshold temperature, which is sens...

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Published in:The Journal of chemical physics 2002-04, Vol.116 (15), p.6826-6830
Main Author: Braun, F. N.
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Language:English
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description We derive a form of adhesive interaction between protein globules in solution, developing from the premise that amino-acid residues are able to rearrange around a globule–globule contact. We show in this approach that globules only become adhesive above a certain threshold temperature, which is sensitive to an osmotic modulus characterizing individual globule elasticity. Above the threshold, adhesive strength increases monotonically with temperature, driving a temperature-reversed liquid–liquid phase separation.
doi_str_mv 10.1063/1.1461358
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title Adhesion and liquid–liquid phase separation in globular protein solutions
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