Ricinus communis-based biopolymer and epidermal growth factor regulations on bone defect repair: A rat tibia model

We report the effect of the addition of an epidermal growth factor to a Ricinus communis-based biopolymer in the healing of a rat tibia model. Bone repair and osteointegration after a period of three weeks were evaluated employing photoacoustic spectroscopy and x-ray diffraction. A parallel study wa...

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Bibliographic Details
Published in:Review of Scientific Instruments 2003-01, Vol.74 (1), p.390-392
Main Authors: Mendoza-Barrera, C., Meléndez-Lira, M., Altuzar, V., Tomás, S. A.
Format: Article
Language:English
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Summary:We report the effect of the addition of an epidermal growth factor to a Ricinus communis-based biopolymer in the healing of a rat tibia model. Bone repair and osteointegration after a period of three weeks were evaluated employing photoacoustic spectroscopy and x-ray diffraction. A parallel study was performed at 1, 2, 3, 4, 5, 6, 7, and 8 weeks with energy dispersive x-ray spectroscopy. We conclude that the use of an epidermal growth factor (group EGF) in vivo accelerates the process of bony repair in comparison with other groups, and that the employment of the Ricinus communis-based biopolymer as a bone substitute decreases bone production.
ISSN:0034-6748
1089-7623
DOI:10.1063/1.1518548