Teflon ™ -coated silicon apertures for supported lipid bilayer membranes

We present a method for microfabricating apertures in a silicon substrate using well-known cleanroom technologies resulting in highly reproducible giga-seal resistance bilayer formations. Using a plasma etcher, 150 μ m apertures have been etched through a silicon wafer. Teflon ™ has been chemically...

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Published in:Applied physics letters 2004-10, Vol.85 (15), p.3307-3309
Main Authors: Wilk, S. J., Goryll, M., Laws, G. M., Goodnick, S. M., Thornton, T. J., Saraniti, M., Tang, J., Eisenberg, R. S.
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container_end_page 3309
container_issue 15
container_start_page 3307
container_title Applied physics letters
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creator Wilk, S. J.
Goryll, M.
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description We present a method for microfabricating apertures in a silicon substrate using well-known cleanroom technologies resulting in highly reproducible giga-seal resistance bilayer formations. Using a plasma etcher, 150 μ m apertures have been etched through a silicon wafer. Teflon ™ has been chemically vapor deposited so that the surface resembles bulk Teflon and is hydrophobic. After fabrication, reproducible high resistance bilayers were formed and characteristic measurements of a self-inserted single OmpF porin ion channel protein were made.
doi_str_mv 10.1063/1.1805712
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title Teflon ™ -coated silicon apertures for supported lipid bilayer membranes
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