Microfluidic electrical sorting of particles based on shape in a spiral microchannel

Shape is an intrinsic marker of cell cycle, an important factor for identifying a bioparticle, and also a useful indicator of cell state for disease diagnostics. Therefore, shape can be a specific marker in label-free particle and cell separation for various chemical and biological applications. We...

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Published in:Biomicrofluidics 2014-01, Vol.8 (1), p.014101-014101
Main Authors: DuBose, John, Lu, Xinyu, Patel, Saurin, Qian, Shizhi, Woo Joo, Sang, Xuan, Xiangchun
Format: Article
Language:English
Subjects:
Cell cycle
Computer simulation
Curvature
Dielectrophoresis
Flow paths
Mathematical models
Microchannels
Organic chemistry
Particle sorting
Particle trajectories
Regular
Sheaths
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cited_by cdi_FETCH-LOGICAL-c539t-f76b6a934bc0cfd82a449b6d4727ec885dea2d533f81a228756e6f8ddee6a7113
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creator DuBose, John
Lu, Xinyu
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Xuan, Xiangchun
description Shape is an intrinsic marker of cell cycle, an important factor for identifying a bioparticle, and also a useful indicator of cell state for disease diagnostics. Therefore, shape can be a specific marker in label-free particle and cell separation for various chemical and biological applications. We demonstrate in this work a continuous-flow electrical sorting of spherical and peanut-shaped particles of similar volumes in an asymmetric double-spiral microchannel. It exploits curvature-induced dielectrophoresis to focus particles to a tight stream in the first spiral without any sheath flow and subsequently displace them to shape-dependent flow paths in the second spiral without any external force. We also develop a numerical model to simulate and understand this shape-based particle sorting in spiral microchannels. The predicted particle trajectories agree qualitatively with the experimental observation.
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subjects Cell cycle
Computer simulation
Curvature
Dielectrophoresis
Flow paths
Mathematical models
Microchannels
Organic chemistry
Particle sorting
Particle trajectories
Regular
Sheaths
title Microfluidic electrical sorting of particles based on shape in a spiral microchannel
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