Bovine serum albumin detection and quantitation based on capacitance measurements of liquid crystals

Liquid crystal (LC)-based biosensing is generally limited by the lack of accurate quantitative strategies. This study exploits the unique electric capacitance properties of LCs to establish quantitative assay methods for bovine serum albumin (BSA) biomolecules. By measuring the voltage-dependent ele...

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Bibliographic Details
Published in:Applied physics letters 2016-08, Vol.109 (9)
Main Authors: Lin, Chi-Hao, Lee, Mon-Juan, Lee, Wei
Format: Article
Language:English
Subjects:
Applied physics
Biomolecules
Capacitance
Liquid crystals
Quantitative analysis
R&D
Research & development
Serum albumin
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Summary:Liquid crystal (LC)-based biosensing is generally limited by the lack of accurate quantitative strategies. This study exploits the unique electric capacitance properties of LCs to establish quantitative assay methods for bovine serum albumin (BSA) biomolecules. By measuring the voltage-dependent electric capacitance of LCs under an alternating-current field with increasing amplitude, positive correlations were derived between the BSA concentration and the electric capacitance parameters of LCs. This study demonstrates that quantitative analysis can be achieved in LC-based biosensing through electric capacitance measurements extensively employed in LCD research and development.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.4962169