Magnetic characterization of paramagnetic reagents by particle tracking velocimetry

Magnetic particle characterization determines the quality of magnetic particles and is of great importance in particle technology, drug delivery, cell separation, in vivo diagnostics, and other biomedical applications. The quality of the sample depends on the particle size, intrinsic magnetic proper...

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Bibliographic Details
Published in:Review of scientific instruments 2021-05, Vol.92 (5), p.054103-054103
Main Authors: Sannidhi, Abhinav, Todd, Paul W., Hanley, Thomas R.
Format: Article
Language:English
Subjects:
Beads
Biomedical materials
Iron oxides
Magnetic permeability
Magnetic properties
Magnetic saturation
Magnetism
Magnetization
Particle size
Particle tracking
Particle tracking velocimetry
Particle trajectories
Reagents
Scientific apparatus & instruments
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Summary:Magnetic particle characterization determines the quality of magnetic particles and is of great importance in particle technology, drug delivery, cell separation, in vivo diagnostics, and other biomedical applications. The quality of the sample depends on the particle size, intrinsic magnetic properties of the particles, and the uniformity of these properties. A commercial particle tracking velocimeter was used to record and capture dark field images of particle trajectories in an applied isodynamic magnetic field. The calibrated particle size, magnetophoretic mobility, and additional image data were collected for each magnetic bead imaged. Using twenty-one different de-identified calibration beads and transmission electron microscopy to validate the vendor-reported particle size enabled the estimation of intrinsic magnetic properties, namely, apparent magnetic susceptibility and saturation magnetization, of individual paramagnetic particles. The distributions of volume magnetic susceptibility based on the magnetophoretic mobility and size of the particle for different magnetic beads were determined and displayed as two-parameter distributions. The measured apparent susceptibility and saturation magnetization were found to be directly proportional to the percentage of iron oxide in the reagent particles.
ISSN:0034-6748
1089-7623
DOI:10.1063/5.0039374