Three-dimensional Lagrangian coherent structures in patients with aortic regurgitation

Understanding blood transport in cardiovascular flows is important for managing patients with cardiovascular disease. In this study, three-dimensional Lagrangian coherent structures have been extracted for the first time in both healthy patients and patients with aortic regurgitation. To achieve thi...

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Bibliographic Details
Published in:Physics of fluids (1994) 2024-01, Vol.36 (1)
Main Authors: Abdallah, Wissam, Darwish, Ahmed, Garcia, Julio, Kadem, Lyes
Format: Article
Language:English
Subjects:
Aorta
Blood
Coherence
Computational efficiency
Magnetic resonance imaging
Systole
Velocity distribution
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Summary:Understanding blood transport in cardiovascular flows is important for managing patients with cardiovascular disease. In this study, three-dimensional Lagrangian coherent structures have been extracted for the first time in both healthy patients and patients with aortic regurgitation. To achieve this, a computationally efficient approach based on Lagrangian descriptors was employed with four-dimensional (4D) magnetic resonance imaging velocity fields. In healthy subjects, Lagrangian coherent structures analysis revealed well-defined mitral jet structures during early filling, directing flow toward ejection during systole. For patients with aortic regurgitation, complex flow structures included interactions between the mitral and regurgitant jets, indicating altered blood transport mechanisms. This study highlights the ability of Lagrangian descriptors to extract coherent structures from patient-specific 4D flow MRI data in a computationally efficient way. It also underscores the importance of extracting three-dimensional Lagrangian coherent structures to gain a better understanding of the complex interaction between the mitral inflow and the regurgitant jet.
ISSN:1070-6631
1089-7666
DOI:10.1063/5.0184991