Normocapnia improves cerebral oxygen delivery during conventional oxygen therapy in carbon monoxide–exposed research subjects

Study objective: We determine whether maintaining normocapnia during hyperoxic treatment of carbon monoxide–exposed research subjects improves cerebral oxygen delivery. Methods: This experiment used a randomized, single-blinded, crossover design. We exposed 14 human research subjects to carbon monox...

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Bibliographic Details
Published in:Annals of emergency medicine 2002-12, Vol.40 (6), p.611-618
Main Authors: Rucker, Joshua, Tesler, Janet, Fedorko, Ludwik, Takeuchi, Akinori, Mascia, Luciana, Vesely, Alex, Kobrossi, Sasha, Slutsky, Arthur S., Volgyesi, George, Iscoe, Steve, Fisher, Joseph A.
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Flow Velocity
Carbon Monoxide Poisoning - drug therapy
Carbon Monoxide Poisoning - physiopathology
Cerebrovascular Circulation
Cross-Over Studies
Emergency and intensive respiratory care
Female
Humans
Intensive care medicine
Male
Medical sciences
Middle Aged
Oxygen - administration & dosage
Oxygen - blood
Oxygen - therapeutic use
Single-Blind Method
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Summary:Study objective: We determine whether maintaining normocapnia during hyperoxic treatment of carbon monoxide–exposed research subjects improves cerebral oxygen delivery. Methods: This experiment used a randomized, single-blinded, crossover design. We exposed 14 human research subjects to carbon monoxide until their carboxyhemoglobin levels reached 10% to 12%. We then treated each research subject with 60 minutes of hyperoxia with or without normocapnia. Research subjects returned after at least 24 hours, were reexposed to carbon monoxide, and were given the alternate treatment. Relative changes in cerebral oxygen delivery were calculated as the product of blood oxygen content and middle cerebral artery velocity (an index of cerebral blood flow) as measured by transcranial Doppler ultrasonography. Results: Maintaining normocapnia during hyperoxic treatment resulted in significantly higher cerebral oxygen delivery compared with standard oxygen treatment (P
ISSN:0196-0644
1097-6760
DOI:10.1067/mem.2002.129723