Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism

Increased oxidative stress has been speculated to be one possible mechanism of ethanol toxicity. This study evaluates malondialdehyde (MDA) and protein carbonyl content in serum as markers of oxidative stress and DNA damage in lymphocytes in the same patients with chronic alcoholism. Patients with c...

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Bibliographic Details
Published in:The Journal of laboratory and clinical medicine 2000-10, Vol.136 (4), p.287-291
Main Authors: Mutlu-Türkoğlu, Ümit, Doğru-Abbasoğlu, Semra, Aykaç-Toker, Gülçin, Mirsal, Hasan, Beyazyürek, Mansur, Uysal, Müjdat
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - blood
Alcoholism - genetics
Alcoholism - metabolism
Aspartate Aminotransferases - blood
Biological and medical sciences
Central Nervous System Depressants - toxicity
Chronic Disease
Digestive system
DNA Damage
Ethanol - toxicity
Female
Humans
Hydrogen Peroxide
Investigative techniques, diagnostic techniques (general aspects)
Lipid Metabolism
Lymphocytes - enzymology
Male
Malondialdehyde - blood
Medical sciences
Middle Aged
Oxidative Stress - physiology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Serum Albumin - metabolism
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Summary:Increased oxidative stress has been speculated to be one possible mechanism of ethanol toxicity. This study evaluates malondialdehyde (MDA) and protein carbonyl content in serum as markers of oxidative stress and DNA damage in lymphocytes in the same patients with chronic alcoholism. Patients with chronic alcoholism showed a significant increase in MDA levels and protein carbonyl content of their serum as compared with non-alcoholic control subjects. Increases in endogenous and H2O2-induced DNA damage were also observed in lymphocytes of patients with chronic alcoholism. In addition, there were significant correlations between endogenous and H2O2-induced DNA damage and serum MDA or protein carbonyl content in patients with chronic alcoholism. These results clearly indicate the presence of oxidative stress in patients with chronic alcoholism. (J Lab Clin Med 2000;136:287-91)
ISSN:0022-2143
1532-6543
DOI:10.1067/mlc.2000.109097