Preterm delivery in women with pregestational diabetes mellitus or chronic hypertension relative to women with uncomplicated pregnancies

• Published in: American journal of obstetrics and gynecology 2000-12, Vol.183 (6), p.1520-1524
• Main Authors: Sibai, Baha M., Caritis, Steve N., Hauth, John C., MacPherson, Cora, VanDorsten, J.Peter, Klebanoff, Mark, Landon, Mark, Paul, Richard H., Meis, Paul J., Miodovnik, Menachem, Dombrowski, Mitchell P., Thurnau, Gary R., Moawad, Atef H., Roberts, James
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Diseases of mother, fetus and pregnancy; Gynecology. Andrology. Obstetrics; Hypertension; indicated preterm delivery; Medical sciences; pregestational diabetes mellitus; Pregnancy. Fetus. Placenta; spontaneous preterm delivery
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1067/mob.[phone]

Objective: The purpose of this study was to compare the rates of indicated and spontaneous preterm delivery among women with chronic hypertension or pregestational diabetes mellitus with the rates among healthy women. Study Design: This was a secondary analysis of data from healthy women with singleton gestations enrolled in a prospective observational study for prediction of preterm delivery (control group, n = 2738), women with pregestational diabetes mellitus requiring insulin therapy (n = 461), and women with chronic hypertension (n = 761). The two latter groups were enrolled in a randomized multicenter trial for prevention of preeclampsia. The main outcome measures were rates of preterm delivery, either spontaneous (preterm labor or rupture of membranes) or indicated (for maternal or fetal reasons), and neonatal outcomes. Results: The overall rates of preterm delivery were significantly higher among women with diabetes mellitus (38%) and hypertension (33.1%) than among control women (13.9%). Rates were also significantly higher for delivery at