Heparin-induced thrombocytopenia is rare in pregnancy

Objective: The indications for heparin use during pregnancy are expanding; however, heparin is associated with serious adverse effects including heparin-induced thrombocytopenia. Low-molecular-weight heparin is expensive but is associated with less frequent occurrences of heparin-induced thrombocyto...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2001-07, Vol.185 (1), p.148-152
Main Authors: Fausett, M.Bardett, Vogtlander, M., Lee, R.M., Esplin, M.S., Branch, D.W., Rodgers, G.M., Silver, R.M.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cohort Studies
Drug toxicity and drugs side effects treatment
Female
Heparin
Heparin - adverse effects
heparininduced thrombocytopenia
Humans
low-molecular-weight heparin
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Pregnancy
Pregnancy Complications, Cardiovascular - drug therapy
Regression Analysis
Retrospective Studies
thrombocytopenia
Thrombocytopenia - chemically induced
Thrombophlebitis - drug therapy
Thrombosis - drug therapy
Thrombosis - prevention & control
Toxicity: blood
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Summary:Objective: The indications for heparin use during pregnancy are expanding; however, heparin is associated with serious adverse effects including heparin-induced thrombocytopenia. Low-molecular-weight heparin is expensive but is associated with less frequent occurrences of heparin-induced thrombocytopenia in the nonpregnant population. However, the incidence of heparin-induced thrombocytopenia during pregnancy is unknown. The purpose of this study was to compare the incidence of heparin-induced thrombocytopenia in pregnant and nonpregnant women. Study Design: This is a retrospective cohort comparison. Pregnant and nonpregnant women were identified by means of diagnosis related group and Current Procedural Terminology code searches at three medical centers in Utah; the incidence of heparin-induced thrombocytopenia in the two groups was compared. Results: There were 10 (4%) cases of thrombocytopenia among 244 heparin-treated pregnant patients and 26 (11%) cases among the 244 nonpregnant controls. There were no cases of heparin-induced thrombocytopenia in the pregnant group, but there were 10 (4%) cases in the control group (P =.0014). Conclusion: Heparin-induced thrombocytopenia is extremely rare in pregnant women. (Am J Obstet Gynecol 2001;185:148-52.)
ISSN:0002-9378
1097-6868
DOI:10.1067/mob.2001.114690