Prevalence of vulvovaginal candidiasis and susceptibility to fluconazole in women

Objective: The purpose of this study was to determine the prevalence of vaginal colonization by Candida with the use of a rapid detection method, to examine the determinants of vaginal candidiasis, and to evaluate susceptibility for fluconazole. Study Design: Vaginal swabs were collected from unsele...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2002-09, Vol.187 (3), p.569-574
Main Authors: Bauters, Tiene G.M., Dhont, Marc A., Temmerman, Marleen I.L., Nelis, Hans J.
Format: Article
Language:English
Subjects:
Adult
Aged
antifungal
Antifungal Agents - pharmacology
Biological and medical sciences
Candida - drug effects
Candidiasis, Vulvovaginal - epidemiology
Contraceptives, Oral - adverse effects
Estrogen Replacement Therapy - adverse effects
Female
Fluconazole - pharmacology
Human mycoses
Humans
Infectious diseases
Medical sciences
Menstrual Cycle
Microbial Sensitivity Tests
Middle Aged
Mycoses
Mycoses of the genital system
Pregnancy
Prevalence
susceptibility
Vulvovaginal candidiasis
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Summary:Objective: The purpose of this study was to determine the prevalence of vaginal colonization by Candida with the use of a rapid detection method, to examine the determinants of vaginal candidiasis, and to evaluate susceptibility for fluconazole. Study Design: Vaginal swabs were collected from unselected women at the outpatient clinic of the Department of Obstetrics and Gynecology. A differentiation was made between patients with a positive and a negative potassium hydroxide examination. Results: Six hundred twelve women were recruited, of whom 39 women (6.3%) had clinical candidiasis. The overall rate of yeast colonization was 20.1%. Candida albicans was isolated most frequently(68.3%), followed by C glabrata (16.3%) and C parapsilosis (8.9%). Clinical candidiasis was related positively with the state of estrogen impregnation. In vitro susceptibility testing by the National Committee for Clinical Laboratory Standards method for fluconazole revealed that 21.1% of the isolates were resistant. Conclusion: More than 20% of the unselected women were colonized with Candida species. Hyperestrogenemia was associated with an increased vulvovaginal colonization by Candida. Surprisingly, 21% of the isolates was resistant to fluconazole, according to the National Committee for Clinical Laboratory Standards method. (Am J Obstet Gynecol 2002;187:569-74.)
ISSN:0002-9378
1097-6868
DOI:10.1067/mob.2002.125897