Cardiac dysfunction in mild primary hyperparathyroidism assessed by radionuclide angiography and echocardiography before and after parathyroidectomy

Background. Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity for reasons that are incompletely understood. The present study was undertaken to evaluate the effects of parathyroidectomy on cardiac function especially in patients with mild PHPT. Methods. Fifty p...

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Bibliographic Details
Published in:Surgery 2002-12, Vol.132 (6), p.1126-1132
Main Authors: Almqvist, Erik G., Bondeson, Anne-Greth, Bondeson, Lennart, Nissborg, Anders, Smedgård, Peter, Svensson, Sven-Eric
Format: Article
Language:English
Subjects:
Aged
Echocardiography
Female
Humans
Hyperparathyroidism - complications
Hyperparathyroidism - surgery
Male
Middle Aged
Parathyroidectomy
Prospective Studies
Radionuclide Imaging
Stroke Volume
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - etiology
Ventricular Function, Left
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Summary:Background. Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity for reasons that are incompletely understood. The present study was undertaken to evaluate the effects of parathyroidectomy on cardiac function especially in patients with mild PHPT. Methods. Fifty patients with mild PHPT (serum calcium, 2.55 to 2.95 mmol/L) were randomized to parathyroidectomy either directly (group A) or after 1 year of observation (group B). Equilibrium radionuclide angiography (ERNA) at rest and at exercise was performed in addition to echocardiography on all patients at inclusion in the study and 1 and 2 years later. Results. Left ventricular mass index was larger (P
ISSN:0039-6060
1532-7361
DOI:10.1067/msy.2002.128692