Synthesis and Properties of π-Complexes of Morphine Alkaloids with Palladium

Treatment of 6β-chloro-6-deoxycodeine 1 with Pd(PPh3)4 yields 6-demethoxythebaine 2 and the π-allylic palladium complex 3, which further reacts with RZnX to give the cross-coupling product of the allylic ligand and R (compounds 5 and 6, respectively). The same products are formed upon reaction of 6β...

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Bibliographic Details
Published in:Mendeleev communications 1995, Vol.5 (1), p.22-23
Main Authors: Kalinin, Valery N., Belyakova, Irina L., Derunov, Vladimir V., Park, Jin K., Schmidhammer, Helmut
Format: Article
Language:English
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Summary:Treatment of 6β-chloro-6-deoxycodeine 1 with Pd(PPh3)4 yields 6-demethoxythebaine 2 and the π-allylic palladium complex 3, which further reacts with RZnX to give the cross-coupling product of the allylic ligand and R (compounds 5 and 6, respectively). The same products are formed upon reaction of 6β-chloro-6-deoxycodeine 1 with RZnX in the presence of catalytic amounts of Pd(PPh3)4.
ISSN:0959-9436
DOI:10.1070/MC1995v005n01ABEH000443