1,3,4-Oxa(thia)diazino [ i,j]-annelated quinolines: a new type of key intermediate in the synthesis of tricyclic fluoroquinolones

The synthesis of new derivatives of 1,3,4-oxa(thia)diazino[6,5,4- i,j]quinolines, which have a structure that is very similar to the ofloxacin skeleton, by intramolecular cyclizations of ethyl 3-(R-carbonylhydrazino)- and 3-(R-thiocarbonylhydrazino)-substituted 2-polyfluorobenzoyl acrylates, is desc...

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Bibliographic Details
Published in:Mendeleev communications 1998, Vol.8 (4), p.131-132
Main Authors: Lipunova, Galina N., Nosova, Emiliya V., Charushin, Valerii N., Sidorova, Larisa P., Chasovskikh, Olga M.
Format: Article
Language:English
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Summary:The synthesis of new derivatives of 1,3,4-oxa(thia)diazino[6,5,4- i,j]quinolines, which have a structure that is very similar to the ofloxacin skeleton, by intramolecular cyclizations of ethyl 3-(R-carbonylhydrazino)- and 3-(R-thiocarbonylhydrazino)-substituted 2-polyfluorobenzoyl acrylates, is described.
ISSN:0959-9436
DOI:10.1070/MC1998v008n04ABEH000986