Death of Injured Neurons Caused by the Precursor of Nerve Growth Factor

Because the adult mammalian brain has a very limited capacity to replace neurons lost after lesion, understanding the mechanisms regulating their survival or elimination is of special significance. A recent study reveals that cutting the axons of a neuronal population involved in movement control le...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2004-04, Vol.101 (16), p.5703-5704
Main Author: Barde, Y-A
Format: Article
Language:English
Subjects:
Animals
Brain
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - physiology
Cell Death - physiology
Cell lines
Cholinergics
Commentaries
Gene expression regulation
Lesions
Mammals
Nerve Growth Factor - physiology
Nerves
Neurology
Neurons
Neurons - cytology
Neuroscience
Pharmacology
Protein Precursors - physiology
Proteins
Receptors
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Summary:Because the adult mammalian brain has a very limited capacity to replace neurons lost after lesion, understanding the mechanisms regulating their survival or elimination is of special significance. A recent study reveals that cutting the axons of a neuronal population involved in movement control leads to a progressive and dramatic increase of pro-nerve growth factor (NGF) in brain fluids.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0401374101