Microinversions in mammalian evolution

We propose an approach for identifying microinversions across different species and show that microinversions provide a source of low-homoplasy evolutionary characters. These characters may be used as "certificates" to verify different branches in a phylogenetic tree, turning the challengi...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2006-12, Vol.103 (52), p.19824-19829
Main Authors: Chaisson, M.J, Raphael, B.J, Pevzner, P.A
Format: Article
Language:English
Subjects:
Animals
Bioinformatics
Biological Evolution
Biological Sciences
Biological taxonomies
Computational Biology
Evolution
Genetic Vectors - genetics
Genomes
Genomics
Humans
Mammals
Phylogenetics
Phylogeny
Physical Sciences
Sequencing
Vertices
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Summary:We propose an approach for identifying microinversions across different species and show that microinversions provide a source of low-homoplasy evolutionary characters. These characters may be used as "certificates" to verify different branches in a phylogenetic tree, turning the challenging problem of phylogeny reconstruction into a relatively simple algorithmic problem. We estimate that there exist hundreds of thousands of microinversions in genomes of mammals from comparative sequencing projects, an untapped source of new phylogenetic characters.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0603984103